---
title: 'Advantage of Microdosing GLPs'
source: 'https://youtube.com/watch?v=C0RyMr9s3Hw'
video_id: 'C0RyMr9s3Hw'
date: 2026-09-24
duration_sec: 70
channel: 'Andrew Huberman'
---

# Advantage of Microdosing GLPs

> Source: [Advantage of Microdosing GLPs](https://youtube.com/watch?v=C0RyMr9s3Hw)

## Summary

The video explains the dangers of abruptly stopping GLP-1 medications like semaglutide, highlighting muscle loss and body composition worsening with each cycle. It recommends microdosing or a bridging plan to maintain results.

### Key Points

- **GLP-1s Are Lifelong** [00:00] — Stopping GLP-1s leads to weight regain and health issues; they are intended as lifelong medications.
- **Lean Mass Loss** [00:12] — About one-third of weight lost is lean mass (muscle, some bone).
- **Cycling Worsens Composition** [00:25] — Cycling on and off shifts body composition to more fat and less muscle each cycle, making you worse off.
- **Microdose Strategy** [00:39] — Instead of stopping, microdose to find a maintenance dose that keeps weight off and maintains well-being.
- **Bridging Plan Required** [00:52] — A game plan is essential: either microdose or bridge to a procedure to keep weight off long-term.

## Transcript

You stop the GLP-1s, there's problems, right? This is not meant to be stopped. These are kind of lifelong medicines. Instead of stopping it, just go to microdosing and you'll find a spot, hopefully, you know, not everyone does, but you'll find a spot
where you keep the weight off, you feel good, and you're not taking as much of the med. Now, the problem with coming off of them is, especially with the original drugs, you know, like semaglutide's an example, right?
Where when you lose weight, about a third of the weight you lose would be lean mass, right? So most muscle, right? Maybe some bone, et cetera. And the problem is when you cycle on and off, right? So say you come off of it and you put your weight back on, you're not putting the lean
mass back on, okay? You're putting the fat back on. So now you've shifted your body composition to be less favorable than before you were on the GLP-1. And then you go on it again and you lose weight again and you lose a little more muscle. And then you go off and you put more fat on,
not more muscle. So now basically you're taking your body composition and shifting it worse every every cycle. So there has to be a game plan. If you're coming off the GLP-1, you need either to microdose it or have a bridging plan to a procedure or something else, which will keep the weight off
for you.